Modifying functional brain networks in focal epilepsy by manual visceral-osteopathic stimulation of the vagus nerve at the abdomen

Non-invasive transcutaneous vagus nerve stimulation elicits similar therapeutic effects as invasive stimulation, offering a potential treatment alternative for wide range of diseases, including epilepsy. Here, we present novel, non-invasive the nerve, which is performed manually viscero-osteopathically on abdomen (voVNS). We explore impact short-term voVNS various local and global characteristics EEG-derived, large-scale evolving functional brain networks from group 20 subjects with without observe differential voVNS-mediated alterations these that can be interpreted reconfiguration modification their stability robustness properties. Clearly, future studies are necessary to assess such non-pharmaceutical intervention clinical decision-making in However, our findings may add current discussion importance gut-brain axis health disease. Clinical Trial Registration : https://drks.de/search/en/trial/DRKS00029914 , identifier DRKS00029914